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General synthesis of substituted 1,2-dihydropyridines

AuthorsTejedor, David ; Cotos, Leandro ; Méndez-Abt, Gabriela ; García-Tellado, Fernando
Issue Date6-Oct-2014
PublisherAmerican Chemical Society
CitationJournal of Organic Chemistry 79: 10655- 10661 (2014)
AbstractA general and practical metal-free protocol for the synthesis of 1,2-dihydropyridines with wide structural/functional diversity at the ring and featuring mono, double, or spiro substitution at the sp3 position is described. The protocol entails a microwave-assisted domino reaction of a propargyl vinyl ether (secondary or tertiary) and a primary amine (aliphatic or aromatic) in toluene or methanol. © 2014 American Chemical Society.
Publisher version (URL)http://dx.doi.org/10.1021/jo501991s
Identifiersissn: 1520-6904
e-issn: 1520-6904
Appears in Collections:(IPNA) Artículos
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