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Solvent-Free Microwave-Assisted Efficient Synthesis of 4,4-Disubstituted 2-Oxazolines

AuthorsGarcía-Tellado, Fernando ; Loupy, André; Petit, Alain; Marrero-Terrero, Alma Leilani
Nitrogen heterocycles
Carboxylic acids
Amino alcohols
Issue Date3-Nov-2003
PublisherJohn Wiley & Sons
CitationEuropean Journal of Organic Chemistry 2003(22): 4387-4391 (2003)
Abstract4,4-Disubstituted 2-oxazolines have been synthesized by a microwave-promoted solvent-free direct condensation of carboxylic acids and disubstituted -amino alcohols in good to excellent yields. Zinc oxide is a very good solid support in cases where a Lewis acid is required. The method described herein is a very good, safe, clean, economical, and environmentally friendly alternative to the classical procedures.
Description5 pages, 3 tables.
Publisher version (URL)http://dx.doi.org/10.1002/ejoc.200200469
Appears in Collections:(IPNA) Artículos
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