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Closed Access item Is it true that coeliacs do not digest gliadin? Degradation pattern of gliadin in coeliac disease small intestinal mucosa

Authors:Bernardo, D.
Garrote, José Antonio
Nadal, Inmaculada
León, A. J.
Clavo, C.
Fernández-Salazar, Luis
Blanco Quirós, Alfredo
Sanz, Yolanda
Arranz, Eduardo
Issue Date:Jun-2009
Publisher:BMJ Publishing Group
Citation:Gut 58(6): 886-887 (2009)
Abstract:Prolyl-endopeptidase supplementation has been proposed to favour gliadin degradation as an alternative treatment for coeliac disease (CD), although the real usefulness of this therapy in vivo is still under discussion. However, our data point to alternative treatments aiming to modify the intestinal microbiota in patients with CD by the use of probiotics and/or prebiotics. We propose that the induction of gliadin proteolysis in the human gut might not be the solution but the origin of CD.
Description:Adjunta Nota de Prensa del CSIC.
Publisher version (URL):http://dx.doi.org/10.1136/gut.2008.167296
URI:http://hdl.handle.net/10261/13216
ISSN:0017-5749 (Print)
1468-3288 (Online)
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