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Título : Is it true that coeliacs do not digest gliadin? Degradation pattern of gliadin in coeliac disease small intestinal mucosa
Autor : Bernardo, David, Garrote, José Antonio, Nadal, Inmaculada, León, A. J., Clavo, C., Fernández-Salazar, Luis, Blanco Quirós, Alfredo, Sanz, Yolanda, Arranz, Eduardo
Fecha de publicación : Jun-2009
Editor: BMJ Publishing Group
Resumen: Prolyl-endopeptidase supplementation has been proposed to favour gliadin degradation as an alternative treatment for coeliac disease (CD), although the real usefulness of this therapy in vivo is still under discussion. However, our data point to alternative treatments aiming to modify the intestinal microbiota in patients with CD by the use of probiotics and/or prebiotics. We propose that the induction of gliadin proteolysis in the human gut might not be the solution but the origin of CD.
Descripción : Adjunta Nota de Prensa del CSIC.
Versión del editor:
ISSN: 0017-5749 (Print)
1468-3288 (Online)
DOI: 10.1136/gut.2008.167296
Citación : Gut 58(6): 886-887 (2009)
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