English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/131683
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

New cationic vesicles prepared with double chain surfactants from arginine: Role of the hydrophobic group on the antimicrobial activity and cytotoxicity

AuthorsPinazo, Aurora; Petrizelli, V.; Bustelo, M.; Pons, Ramon; Vinardell, María Pilar; Mitjans, Montserrat; Manresa, A.; Pérez, Lourdes F.
KeywordsAntimicrobial activity
Arginine-based surfactants
Cationic vesicles
Cytotoxicity
Issue Date1-May-2016
PublisherElsevier
CitationColloids and Surfaces B: Biointerfaces 141:19-27(2016)
AbstractCationic double chain surfactants have attracted much interest because they can give rise to cationic vesicles that can be used in biomedical applications. Using a simple and economical synthetic approach, we have synthesized four double-chain surfactants with different alkyl chain lengths (LANHC. x). The critical aggregation concentration of the double chain surfactants is at least one order of magnitude lower than the CMC of their corresponding single-chain LAM and the solutions prepared with the LANHC. x contain stable cationic vesicles. Encouragingly, these new arginine derivatives show very low haemolytic activity and weaker cytotoxic effects than conventional dialkyl dimethyl ammonium surfactants. In addition, the surfactant with the shortest alkyl chain exhibits good antimicrobial activity against Gram-positive bacteria. The results show that a rational design applied to cationic double chain surfactants might serve as a promising strategy for the development of safe cationic vesicular systems. © 2016 Elsevier B.V.
Publisher version (URL)http://dx.doi.org/10.1016/j.colsurfb.2016.01.020
URIhttp://hdl.handle.net/10261/131683
DOI10.1016/j.colsurfb.2016.01.020
Appears in Collections:(IQAC) Artículos
Files in This Item:
File Description SizeFormat 
2016_Colloids and Surfaces B.docx1,6 MBMicrosoft Word XMLView/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.