The oxidized proteome of peripheral blood mononuclear cells: a valuable repository for clinical proteomics

Abstract

PBMCs and its specific cell subsets have allowed for a very broad collection of applications such as in vitro cell-based assays to study the immune response to a given stimuli, or to monitor in vivo or ex vivo changes before and after a drug treatment. More importantly, they are an easily accessible cellular part of the blood, and they are the only component of the blood that could have a gene expression activity. Access to complete atlas of the gene expression and posttranslational modifications in PBMCs will permit more sophisticated studies such us the selection of potential biomarkers that could be used for many purposes ranging from diagnostic, prognosis or even help selecting the appropriate therapy for a patient.