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Title

Cross-linked chitosan/liposome hybrid system for the intestinal delivery of quercetin

AuthorsCaddeo, Carla; Díez-Sales, Octavio; Pons, Ramon; Carbone, C.; Ennas, Guido; Puglisi, Giovanni; Fadda, Anna Maria; Manconi, Maria
KeywordsChitosan
Liposomes
Intestinal delivery
Quercetin
Issue Date1-Jan-2016
PublisherElsevier
CitationJournal of Colloid and Interface Science
AbstractQuercetin is a flavonoid with antioxidant/anti-inflammatory properties, poorly absorbed when administered orally. To increase its bioavailability and optimize its release in the intestine, a hybrid system made of liposomes coated with cross-linked chitosan, named TPP-chitosomes, was developed and characterized by light scattering, transmission electron microscopy, differential scanning calorimetry, X-ray powder diffraction and Turbiscan® technology. The TPP-chitosomes were nanosized (~180. nm), fairly spherical in shape and unilamellar. The actual coating of the surface of liposomes with the cross-linked chitosan was demonstrated by Small-Angle X-ray Scattering.The release of quercetin in simulated gastric and intestinal pH was investigated, the results showing that the system provided resistance to acidic conditions, and promoted the release in alkaline pH, mimicking the intestinal environment.The proposed hybrid system represents a promising combination of nanovesicles and chitosan for the delivery of quercetin to the intestine in the therapy of oxidative stress/inflammation related disorders.
Publisher version (URL)http://www.sciencedirect.com/science/article/pii/S0021979715301843
URIhttp://hdl.handle.net/10261/130091
DOI10.1016/j.jcis.2015.09.013
Appears in Collections:(IQAC) Artículos
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