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Título: | Cell migration and division in amoeboid-like fission yeast |
Autor: | Flor-Parra, Ignacio CSIC ORCID; Bernal, Manuel CSIC ORCID; Zhurinsky, Jacob; Daga, Rafael R. CSIC ORCID | Palabras clave: | Turgor pressure Morphogenesis Fission yeast Cell migration Cytokinesis |
Fecha de publicación: | 2014 | Editor: | Company of Biologists | Citación: | Biology Open 3(1): 108-115 (2014) | Resumen: | Yeast cells are non-motile and are encased in a cell wall that supports high internal turgor pressure. The cell wall is also essential for cellular morphogenesis and cell division. Here, we report unexpected morphogenetic changes in a Schizosaccharomyces pombe mutant defective in cell wall biogenesis. These cells form dynamic cytoplasmic protrusions caused by internal turgor pressure and also exhibit amoeboid-like cell migration resulting from repeated protrusive cycles. The cytokinetic ring responsible for cell division in wild-type yeast often fails in these cells; however, they were still able to divide using a ring-independent alternative mechanism relying on extrusion of the cell body through a hole in the cell wall. This mechanism of cell division may resemble an ancestral mode of division in the absence of cytokinetic machinery. Our findings highlight how a single gene change can lead to the emergence of different modes of cell growth, migration and division. | Descripción: | This is an Open Access article distributed under the terms of the Creative Commons Attribution License. | Versión del editor: | http://dx.doi.org/10.1242/bio.20136783 | URI: | http://hdl.handle.net/10261/129461 | DOI: | 10.1242/bio.20136783 | Identificadores: | doi: 10.1242/bio.20136783 e-issn: 2046-6390 |
Aparece en las colecciones: | (CABD) Artículos |
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