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Title

Screening for natural anticancer agents using a fission yeast bioassay

AuthorsSánchez-Picó, Ángeles; León-González, Antonio J.; Martín-Cordero, Carmen; Daga, Rafael R.
KeywordsFlavonoid
2′,4′-Dihydroxychalcone (DHC)
Antiproliferative
Schizosaccharomyces pombe
Fission yeast
Corema album
Ericaceae
Issue Date2014
PublisherElsevier
CitationPhytochemistry Letters 8: 184-189 (2014)
AbstractA fission-yeast bioassay guided screening on several plant extracts is carried out to search for anticancer agents, and an extract from leaves of Corema album (L.) D. Don (Ericaceae) is found to have antiproliferative activity. Further fractionation afforded 2′,4′-dihydroxychalcone (DHC) as the main cytotoxic compound present in the extract. Our detailed biological analysis shows that antiproliferative activity of this flavonoid is likely due to its ability to induce DNA damage which blocks cell cycle progression.
URIhttp://hdl.handle.net/10261/129390
DOI10.1016/j.phytol.2013.09.011
Identifiersdoi: 10.1016/j.phytol.2013.09.011
issn: 1874-3900
Appears in Collections:(CABD) Artículos
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