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C. elegans epigenetic regulation in development and aging

AuthorsGonzález-Aguilera, Cristina ; Palladino, Francesca; Askjaer, Peter
Transcriptional silencing
Small RNA
Caenorhabditis elegans
Chromatin organization
Issue Date2014
PublisherOxford University Press
CitationBriefings in Functional Genomics 13(3): 223-234 (2014)
AbstractThe precise developmentalmap of the Caenorhabditis elegans cell lineage, as well as a complete genome sequence and feasibility of genetic manipulation make this nematode species highly attractive to study the role of epigenetics during development. Genetic dissection of phenotypical traits, such as formation of egg-laying organs or starvation- resistant dauer larvae, has illustrated how chromatin modifiers may regulate specific cell-fate decisions and behavioral programs. Moreover, the transparent body of C. elegans facilitates non-invasive microscopy to study tissue-specific accumulation of heterochromatin at the nuclear periphery. We also review here recent findings on how small RNA molecules contribute to epigenetic control of gene expression that can be propagated for several generations and eventually determine longevity.
DescriptionThis is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License.
Publisher version (URL)http://dx.doi.org/10.1093/bfgp/elt048
Identifiersdoi: 10.1093/bfgp/elt048
issn: 2041-2649
e-issn: 2041-2657
Appears in Collections:(CABD) Artículos
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