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PEGylated versus non-PEGylated magnetic nanoparticles as camptothecin delivery system

AuthorsCastillo, Paula M.; Mata, Mario de la ; Casula, María F.; Sánchez-Alcázar, José Antonio ; Zaderenko, Paula
KeywordsCancer therapy
Polyethylene glycol
Iron oxide superparamagnetic nanoparticles
Issue Date2014
PublisherBeilstein-Institut für Literatur der Organischen Chemie
CitationBeilstein Journal of Nanotechnology 5: 1312-1319 (2014)
AbstractCamptothecin (CPT; (S)-(+)-4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-(4H,12H)-dione) is a highly cytotoxic natural alkaloid that has not yet found use as chemotherapeutic agent due to its poor water-solubility and chemical instability and, as a consequence, no effective administration means have been designed. In this work, camptothecin has been successfully loaded into iron oxide superparamagnetic nanoparticles with an average size of 14 nm. It was found that surface modification of the nanoparticles by polyethylene glycol enables loading a large amount of camptothecin. While the unloaded nanoparticles do not induce apoptosis in the H460 lung cancer cell line, the camptothecin-loaded nanoparticle formulations exhibit remarkable proapoptotic activity. These results indicate that camptothecin retains its biological activity after loading onto the magnetic nanoparticles. The proposed materials represent novel materials based on naturally occurring bioactive molecules loaded onto nanoparticles to be used as chemotherapeutic formulations. The procedure seems apt to be extended to other active molecules extracted from natural products. In addition, these materials offer the potential of being further implemented for combined imaging and therapeutics, as magnetic nanoparticles are known to be multifunctional tools for biomedicine.
DescriptionThis is an Open Access article under the terms of the Creative Commons Attribution License.
Publisher version (URL)http://dx.doi.org/10.3762/bjnano.5.144
Identifiersdoi: 10.3762/bjnano.5.144
e-issn: 2190-4286
Appears in Collections:(CABD) Artículos
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