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Título: | Forces shaping a Hox morphogenetic gene network |
Autor: | Sotillos, Sol CSIC ORCID ; Aguilar, Mario CSIC; Castelli-Gair Hombría, James CSIC ORCID | Palabras clave: | Morphogenesis Signaling Realizator gene Homeotic gene Evolution |
Fecha de publicación: | 2013 | Editor: | National Academy of Sciences (U.S.) | Citación: | Proceedings of the National Academy of Sciences of the USA 110(11): 4303-4308 (2013) | Resumen: | The Abdominal-B selector protein induces organogenesis of the posterior spiracles by coordinating an organ-specific gene network. The complexity of this network begs the questions of how it originated and what selective pressures drove its formation. Given that the network likely formed in a piecemeal fashion, with elements recruited sequentially, we studied the consequences of expressing individual effectors of this network in naive epithelial cells.We found that, with exception of the Crossveinless-c (Cv-c) Rho GTPase-activating protein, most effectors exert little morphogenetic effect by themselves. In contrast, Cv-c expression causes cell motility and downregulates epithelial polarity and cell adhesion proteins. These effects differ in cells endogenously expressing Cv-c, which have acquired compensatory mechanisms. In spiracle cells, the down-regulation of polarity and E-cadherin expression caused by Cv-c-induced Rho1 inactivation are compensated for by the simultaneous spiracle up-regulation of guanine nucleotide exchange factor (GEF) proteins, cell polarity, and adhesion molecules. Other epithelial cells that have coopted Cv-c to their morphogenetic gene networks are also resistant to Cv-c's deleterious effects. We propose that cooption of a novel morphogenetic regulator to a selector cascade causes cellular instability, resulting in strong selective pressure that leads that same cascade to recruitmolecules that compensate it. This experimental-based hypothesis proposes how the frequently observed complex organogenetic gene networks are put together. | Versión del editor: | http://dx.doi.org/10.1073/pnas.1212970110 | URI: | http://hdl.handle.net/10261/129274 | DOI: | 10.1073/pnas.1212970110 | Identificadores: | doi: 10.1073/pnas.1212970110 e-issn: 1091-6490 |
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