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Title

Is inflammation a mitochondrial dysfunction-dependent event in fibromyalgia?

AuthorsCordero, Mario D. ; Díaz-Parrado, Eduardo; Carrión Rodríguez, Ángel Manuel ; Alfonsi, Simona; Sánchez-Alcázar, José Antonio ; Bullón, Pedro; Battino, Maurizio; Miguel, Manuel de
Issue Date2013
PublisherMary Ann Liebert
CitationAntioxidants and Redox Signaling 18(7): 800-807 (2013)
AbstractFibromyalgia (FM) is a complex disorder that affects up to 5% of the general population worldwide. Both mitochondrial dysfunction and inflammation have been implicated in the pathophysiology of FM. We have investigated the possible relationship between mitochondrial dysfunction, oxidative stress, and inflammation in FM. We studied 30 women diagnosed with FM and 20 healthy women. Blood mononuclear cells (BMCs) from FM patients showed reduced level of coenzyme Q10 (CoQ10) and mtDNA contents and high level of mitochondrial reactive oxygen species (ROS) and serum tumor necrosis factor (TNF)-alpha and transcript levels. A significant negative correlation between CoQ10 and TNF-alpha levels (r=-0.588; p<0.01), and a positive correlation between ROS and TNF-alpha levels (r=0.791; p<0.001) were observed accompanied by a significant correlation of visual analogical scale with serum TNF-alpha and transcript levels (r=0.4507; p<0.05 and r=0.7089; p<0.001, respectively). TNF-alpha release was observed in an in vitro (BMCs) and in vivo (mice) CoQ10 deficiency model. Oral CoQ10 supplementation restored biochemical parameters and induced a significant improvement in clinical symptoms (p<0.001). These results lead to the hypothesis that inflammation could be a mitochondrial dysfunction-dependent event implicated in the pathophysiology of FM in several patients indicating at mitochondria as a possible new therapeutic target.
URIhttp://hdl.handle.net/10261/129248
DOI10.1089/ars.2012.4892
Identifiersdoi: 10.1089/ars.2012.4892
issn: 1523-0864
e-issn: 1557-7716
Appears in Collections:(CABD) Artículos
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