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Title

JAK-STAT pathway in Drosophila morphogenesis

Other TitlesFrom organ selector to cell behavior regulator
AuthorsCastelli-Gair Hombría, James ; Sotillos, Sol
KeywordsDrosophila
JAK-STAT
Development
Morphogenesis
Organogenesis
Signaling
Issue Date2013
PublisherLandes Bioscience
Taylor & Francis
CitationJAK-STAT 2(3): e26089 (2013)
AbstractOne of the main contributions of Drosophila to the JAK-STAT field is the study of morphogenesis. JAK-STAT signaling controls the formation of many different structures through surprisingly different morphogenetic behaviors that include induction of cell rearrangements, invagination, folding of tissues, modulation of cell shape, and migration. This variability may be explained by the many transcription factors and signaling molecules STAT regulates at early stages of development. But is STAT just acting as an upstream inducer of morphogenesis or does it have a more direct role in controlling cell behaviors? Here we review what is known about how the canonical phosphorylation of STAT contributes to shaping the embryonic and imaginal structures.
DescriptionThis is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License.
Publisher version (URL)http://dx.doi.org/10.4161/jkst.26089
URIhttp://hdl.handle.net/10261/129226
DOI10.4161/jkst.26089
ISSN2162-3988
E-ISSN2162-3996
Appears in Collections:(CABD) Artículos
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