Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/129204
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Serrano-Bueno, Gloria | es_ES |
dc.contributor.author | Hernández, Agustín | es_ES |
dc.contributor.author | López-Lluch, Guillermo | es_ES |
dc.contributor.author | Pérez-Castiñeira, J. R. | es_ES |
dc.contributor.author | Navas, Plácido | es_ES |
dc.contributor.author | Serrano, Aurelio | es_ES |
dc.date.accessioned | 2016-02-18T11:20:41Z | - |
dc.date.available | 2016-02-18T11:20:41Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Journal of Biological Chemistry 288(18): 13082-13092 (2013) | es_ES |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | http://hdl.handle.net/10261/129204 | - |
dc.description.abstract | Inorganic pyrophosphatases are required for anabolism to take place in all living organisms. Defects in genes encoding these hydrolytic enzymes are considered inviable, although their exact nature has not been studied at the cellular and molecular physiology levels. Using a conditional mutant in IPP1, the Saccharomyces cerevisiae gene encoding the cytosolic soluble pyrophosphatase, we show that respiring cells arrest in S phase upon Ipp1p deficiency, but they remain viable and resume growth if accumulated pyrophosphate is removed. However, fermenting cells arrest in G1/G0 phase and suffer massive vacuolization and eventual cell death by autophagy. Impaired NAD(+) metabolism is a major determinant of cell death in this scenario because demise can be avoided under conditions favoring accumulation of the oxidized pyridine coenzyme. These results posit that the mechanisms related to excess pyrophosphate toxicity in eukaryotes are dependent on the energy metabolism of the cell. | es_ES |
dc.description.sponsorship | This work was supported by grants from the Andalusian Regional Government and the Spanish Ministries of Science and Innovation and of Health, Social Policies, and Equality (to Plan Andaluz de Investigación, Desarrollo e Innovación Groups BIO-261 and BIO-177) and Grants P07-CVI-3082, BFU2007-61887, BFU2010-15622, FIS-PI080500, and P08-CTS-3988, all of them partially funded by European Regional Development Fund program. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | American Society for Biochemistry and Molecular Biology | es_ES |
dc.rights | closedAccess | es_ES |
dc.subject | Autophagy | es_ES |
dc.subject | Cell death | es_ES |
dc.subject | Energy metabolism | es_ES |
dc.subject | NAD | es_ES |
dc.subject | Yeast metabolism | es_ES |
dc.title | Inorganic pyrophosphatase defects lead to cell cycle arrest and autophagic cell death through NAD+ depletion in fermenting yeast | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1074/jbc.M112.439349 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1074/jbc.M112.439349 | es_ES |
dc.identifier.e-issn | 1083-351X | - |
dc.contributor.funder | Junta de Andalucía | es_ES |
dc.contributor.funder | Ministerio de Ciencia e Innovación (España) | es_ES |
dc.contributor.funder | Ministerio de Sanidad, Servicios Sociales e Igualdad (España) | es_ES |
dc.contributor.funder | European Commission | es_ES |
dc.relation.csic | Sí | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100004837 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003751 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100000780 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011011 | es_ES |
dc.identifier.pmid | 23479727 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
Aparece en las colecciones: | (IBVF) Artículos (CABD) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
accesoRestringido.pdf | 15,38 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
22
checked on 13-abr-2024
SCOPUSTM
Citations
33
checked on 24-abr-2024
WEB OF SCIENCETM
Citations
32
checked on 24-feb-2024
Page view(s)
309
checked on 24-abr-2024
Download(s)
99
checked on 24-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.