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dc.contributor.authorLapuente-Brun, Estheres_ES
dc.contributor.authorMoreno-Loshuertos, Raqueles_ES
dc.contributor.authorRodríguez-Hernández, Ángeleses_ES
dc.contributor.authorNavas, Plácidoes_ES
dc.contributor.authorEnríquez, José Antonioes_ES
dc.date.accessioned2016-02-16T12:50:04Z-
dc.date.available2016-02-16T12:50:04Z-
dc.date.issued2013-
dc.identifier.citationScience 340(6140): 1567-1570 (2013)es_ES
dc.identifier.issn0036-8075-
dc.identifier.urihttp://hdl.handle.net/10261/129138-
dc.descriptionReport.-- et al.es_ES
dc.description.abstractThe textbook description of mitochondrial respiratory complexes (RCs) views them as free-moving entities linked by the mobile carriers coenzyme Q (CoQ) and cytochrome c (cyt c). This model (known as the fluid model) is challenged by the proposal that all RCs except complex II can associate in supercomplexes (SCs). The proposed SCs are the respirasome (complexes I, III, and IV), complexes I and III, and complexes III and IV. The role of SCs is unclear, and their existence is debated. By genetic modulation of interactions between complexes I and III and III and IV, we show that these associations define dedicated CoQ and cyt c pools and that SC assembly is dynamic and organizes electron flux to optimize the use of available substrates.es_ES
dc.language.isoenges_ES
dc.publisherAmerican Association for the Advancement of Sciencees_ES
dc.rightsclosedAccesses_ES
dc.titleSupercomplex assembly determines electron flux in the mitochondrial electron transport chaines_ES
dc.typeartículoes_ES
dc.identifier.doi10.1126/science.1230381-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1126/science.1230381es_ES
dc.identifier.e-issn1095-9203-
dc.relation.csices_ES
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