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Title

Supercomplex assembly determines electron flux in the mitochondrial electron transport chain

AuthorsLapuente-Brun, Esther; Moreno-Loshuertos, Raquel; Rodríguez-Hernández, Ángeles ; Navas, Plácido ; Enríquez, José Antonio
Issue Date2013
PublisherAmerican Association for the Advancement of Science
CitationScience 340(6140): 1567-1570 (2013)
AbstractThe textbook description of mitochondrial respiratory complexes (RCs) views them as free-moving entities linked by the mobile carriers coenzyme Q (CoQ) and cytochrome c (cyt c). This model (known as the fluid model) is challenged by the proposal that all RCs except complex II can associate in supercomplexes (SCs). The proposed SCs are the respirasome (complexes I, III, and IV), complexes I and III, and complexes III and IV. The role of SCs is unclear, and their existence is debated. By genetic modulation of interactions between complexes I and III and III and IV, we show that these associations define dedicated CoQ and cyt c pools and that SC assembly is dynamic and organizes electron flux to optimize the use of available substrates.
DescriptionReport.-- et al.
Publisher version (URL)http://dx.doi.org/10.1126/science.1230381
URIhttp://hdl.handle.net/10261/129138
DOI10.1126/science.1230381
ISSN0036-8075
E-ISSN1095-9203
Appears in Collections:(CABD) Artículos
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