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Title

Tanzawaic acids, a chemically novel set of bacterial conjugation inhibitors

AuthorsGetino, María; Fernández-López, Raul; Palencia-Gándara, Carolina; Campos-Gómez, Javier; Sánchez-López, José M.; Martínez, Marta; Fernández, Antonio; Cruz, Fernando de la
Issue Date26-Jan-2016
PublisherPublic Library of Science
CitationPLoS ONE 11(1): e0148098 (2016)
AbstractBacterial conjugation is the main mechanism for the dissemination of multiple antibiotic resistance in human pathogens. This dissemination could be controlled by molecules that interfere with the conjugation process. A search for conjugation inhibitors among a collection of 1,632 natural compounds, identified tanzawaic acids A and B as best hits. They specially inhibited IncW and IncFII conjugative systems, including plasmids mobilized by them. Plasmids belonging to IncFI, IncI, IncL/M, IncX and IncH incompatibility groups were targeted to a lesser extent, whereas IncN and IncP plasmids were unaffected. Tanzawaic acids showed reduced toxicity in bacterial, fungal or human cells, when compared to synthetic conjugation inhibitors, opening the possibility of their deployment in complex environments, including natural settings relevant for antibiotic resistance dissemination.
Publisher version (URL)http://dx.doi.org/10.1371/journal.pone.0148098
URIhttp://hdl.handle.net/10261/128782
DOI10.1371/journal.pone.0148098
ISSN1932-6203
Appears in Collections:(IBBTEC) Artículos
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