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dc.contributor.authorAzeredo, Ritaes_ES
dc.contributor.authorPérez-Sánchez, Jaumees_ES
dc.contributor.authorSitjà-Bobadilla, Ariadnaes_ES
dc.contributor.authorFouz, Belénes_ES
dc.contributor.authorTort, Lluises_ES
dc.contributor.authorAragão, Cláudiaes_ES
dc.contributor.authorOliva-Teles, Aireses_ES
dc.contributor.authorCostas, Benjamínes_ES
dc.date.accessioned2016-02-05T10:07:30Z-
dc.date.available2016-02-05T10:07:30Z-
dc.date.issued2015-10-08-
dc.identifier.citationPLoS ONE 10(10): e0139967 (2015)es_ES
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/10261/128768-
dc.description.abstractInfectious diseases and fish feeds management are probably the major expenses in the aquaculture business. Hence, it is a priority to define sustainable strategies which simultaneously avoid therapeutic procedures and reinforce fish immunity. Currently, one preferred approach is the use of immunostimulants which can be supplemented to the fish diets. Arginine is a versatile amino acid with important mechanisms closely related to the immune response. Aiming at finding out how arginine affects the innate immune status or improve disease resistance of European seabass (Dicentrarchus labrax) against vibriosis, fish were fed two arginine-supplemented diets (1% and 2% arginine supplementation). A third diet meeting arginine requirement level for seabass served as control diet. Following 15 or 29 days of feeding, fish were sampled for blood, spleen and gut to assess cell-mediated immune parameters and immune-related gene expression. At the same time, fish from each dietary group were challenged against Vibrio anguillarum and survival was monitored. Cell-mediated immune parameters such as the extracellular superoxide and nitric oxide decreased in fish fed arginine-supplemented diets. Interleukins and immune-cell marker transcripts were down-regulated by the highest supplementation level. Disease resistance data were in accordance with a generally depressed immune status, with increased susceptibility to vibriosis in fish fed arginine supplemented diets. Altogether, these results suggest a general inhibitory effect of arginine on the immune defences and disease resistance of European seabass. Still, further research will certainly clarify arginine immunomodulation pathways thereby allowing the validation of its potential as a prophylactic strategy.es_ES
dc.description.sponsorshipThis work was partially funded by European Union’s Seventh Framework Programme AQUAEXCEL (Aquaculture Infrastructures for Excellence in European Fish Research, grant agreement no. 262336), AQUAIMPROV (reference NORTE-07-0124-FEDER-000038), PEst-C/MAR/LA0015/2013 and UID/Multi/04423/2013. It was co-financed by the North Portugal Regional Operational Programme (ON.2 - O Novo Norte), under the National Strategic Reference Framework, through the European Regional Development Fund, and through the COMPETE - Operational Competitiveness Programme and national funds through the Fundação para a Ciência e Tecnologia, respectively. RA and BC were supported by Fundação para a Ciência e Tecnologia (grants SFRH/BD/89457/2012 and SFRH/BPD/77210/2011, respectively). Additional funding was obtained from the Generalitat Valenciana through the project REVIDPAQUA (ISIC/2012/003).es_ES
dc.description.sponsorshipUSD 1,350 APC fee funded by the EC FP7 Post-Grant Open Access Pilotes_ES
dc.language.isoenges_ES
dc.publisherPublic Library of Sciencees_ES
dc.relationinfo:eu-repo/grantAgreement/EC/FP7/262336es_ES
dc.relationFP7 post-grant Gold Open Access Pilotes_ES
dc.relation.isversionofPublisher's versiones_ES
dc.rightsopenAccesses_ES
dc.titleEuropean Sea Bass (Dicentrarchus labrax) Immune Status and Disease Resistance Are Impaired by Arginine Dietary Supplementationes_ES
dc.typeartículoes_ES
dc.identifier.doi10.1371/journal.pone.0139967-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1371/journal.pone.0139967es_ES
dc.rights.licensehttp://creativecommons.org/licenses/by/4.0/es_ES
dc.contributor.funderEuropean Commissiones_ES
dc.contributor.funderFundação para a Ciência e a Tecnologia (Portugal)es_ES
dc.contributor.funderGeneralitat Valencianaes_ES
dc.contributor.funderMinistério da Economia (Portugal)es_ES
dc.relation.csices_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100000780es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100001871es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100003359es_ES
dc.identifier.pmid26447480-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
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