English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/128522
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

Differences in ATP generation via glycolysis and oxidative phosphorylation, and relationships with sperm motility, in mouse species

AuthorsTourmente, Maximiliano ; Villar-Moya, Pilar; Rial, Eduardo ; Roldán, Eduardo R. S.
KeywordsATP
Bioenergetics
Cell metabolism
Glycolysis
Mouse
Respiration
Sperm
Issue Date5-Jun-2015
PublisherAmerican Society for Biochemistry and Molecular Biology
CitationJournal of Biological Chemistry 290(33): 20613-20626 (2015)
AbstractMouse sperm produce enough ATP to sustain motility by anaerobic glycolysis and respiration. However, previous studies indicated that an active glycolytic pathway is required to achieve normal sperm function, and identified glycolysis as the main source of ATP to fuel the motility of mouse sperm. All the available evidence has been gathered for the lab mouse, while comparative studies including closely related mouse species have revealed (a) a wide range of variation in sperm motility and ATP production, and (b) that the lab mouse shows comparatively low values in these traits. In this study, we compared the relative reliance on the usage of glycolysis or oxidative phosphorylation as ATP sources for sperm motility between mouse species that exhibit significantly different sperm performance parameters. We found that the sperm of species with higher oxygen consumption/lactate excretion rate ratio were able to produce higher amounts of ATP, achieving higher swimming velocities. Additionally, we show that the species with higher respiration/glycolysis ratio have a higher degree of dependence upon active oxidative phosphorylation. Moreover, we characterize for the first time, two mouse species in which sperm depend on functional oxidative phosphorylation to achieve normal performance. Finally, we discuss that sexual selection through sperm competition could promote adaptations in sperm energetic metabolism tending to increase the usage of oxidative phosphorylation in relation to glycolysis, as this would constitute a more efficient pathway for the generation of ATP (and faster sperm).
Publisher version (URL)http://dx.doi.org/10.1074/jbc.M115.664813 jbc.M115.664813
URIhttp://hdl.handle.net/10261/128522
DOI10.1074/jbc.M115.664813 jbc.M115.664813
ISSN0021-9258
E-ISSN1083-351X
Appears in Collections:(MNCN) Artículos
Files in This Item:
File Description SizeFormat 
J. Biol. Chem. 290(33) 20613-20626 (2015) POSTPRINT.pdf10,69 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.