Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/127145COMPARTIR / EXPORTAR:
 SHARE
 CORE
BASE
|
|
| Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
| Título: | Altered blood gene expression of tumor-related genes (PRKCB, BECN1 and CDKN2A) in Alzheimer’s disease |
Autor: | Antonell, Anna; Sanfeliu, Coral CSIC ORCID; Boya, Patricia CSIC ORCID ; Molinuevo, José Luis | Palabras clave: | Gene expression Blood Alzheimer’s disease Preclinical Autophagy Mitochondria |
Fecha de publicación: | 28-oct-2015 | Resumen: | Alzheimer’s disease (AD) is the most common of the neurodegenerative diseases. Recent diagnostic criteria have defined a preclinical disease phase during which neuropathological substrates are thought to be present in the brain. There is an urgent need to find measurable alterations in this phase as well as a good peripheral biomarker in the blood. We selected a cohort of 100 subjects (controls = 47; preclinical AD = 11; patients with AD = 42) and analyzed whole blood expression of 20 genes by quantitative polymerase chain reaction. The selected genes belonged to calcium-signaling, senescence and autophagy, and mitochondria/oxidative stress pathways. Additionally, two genes associated with an increased risk of developing AD (CLU and BIN1) were also analyzed. We detected significantly different gene expressions of BECN1 and PRKCB between the control and the AD groups; and, of CDKN2A between the control and the preclinical AD groups. Notably, these three genes are also considered tumor suppressor (CDKN2A and BECN1) or tumor promoter (PRKCB) genes. Gene-gene expression Pearson correlations were computed separately for controls and patients with AD. The significant correlations (p<0.001) were represented in a network analysis with Cytoscape tool, which suggested an uncoupling of mitochondriarelated genes in AD group. Whole blood is emerging as a valuable tissue in the study of the physiopathology of AD. | Descripción: | 22 p.-3 fig.-3 tab. Antonell, Anna et al. | Versión del editor: | http://dx.doi.org/10.1007/s12035-015-9483-9 | URI: | http://hdl.handle.net/10261/127145 | DOI: | 10.1007/s12035-015-9483-9 | ISSN: | 0893-7648 | E-ISSN: | 1559-1182 |
| Aparece en las colecciones: | (CIB) Artículos |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| MOLN_Boya_2015.pdf | Postprint | 1,24 MB | Adobe PDF |  Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
12
checked on 29-mar-2024
WEB OF SCIENCETM
Citations
10
checked on 24-feb-2024
Page view(s)
303
checked on 22-abr-2024
Download(s)
310
checked on 22-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.