English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/127092
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Application of a new dynamic gastrointestinal simulator (SIMGI) to study the impact of red wine in colonic metabolism

AuthorsCueva, Carolina ; Jiménez-Girón, Ana ; Muñoz-González, Irene ; Esteban-Fernández, Adelaida ; Gil-Sánchez, Irene ; Dueñas, Montserrat; Martín-Álvarez, Pedro J. ; Pozo-Bayón, Mª Ángeles ; Bartolomé, Begoña ; Moreno-Arribas, M. Victoria
Issue Date2015
CitationFood Research International 72: 149-159 (2015)
AbstractPolyphenols present in wine may favorably influence human health by means of modifying the metabolic activity and/or composition of gut microbiota. The aim of this study was to evaluate the impact of red wine on colonic metabolism using a novel Dynamic Gastrointestinal Simulator (namely SIMGI), inoculated with human feces of healthy volunteers (n. =. 2). Main wine phenolic compounds and their metabolites, ammonium and short-chain fatty acids (SCFAs) as well as main microbial groups were monitored in samples from the three colon compartments - ascending, transverse and descending - after feeding the system with red wine (225. mL). Significant increases were found for gallic acid, protocatechuic acid, 3-. O-methylgallic acid, 4-hydroxybenzoic acid, 3,4-dihydroxyphenylpropionic acid, vanillic acid, syringic acid and salicylic acid after wine feeding. Concurrently, a decrease in ammonium ion and an increase in the proportion of butanoic acid were observed. In turn, the microbiota metabolic activity was found different between the two individuals and among the three compartments, with the main changes occurring in the ascending colon. These results highlight that red wine modulates the metabolic activity of colonic microbiota in vitro, which could be physiologically relevant, and contribute to our understanding on the complex metabolic fate of dietary polyphenols and polyphenols-microbiota interactions.
Identifiersdoi: 10.1016/j.foodres.2015.03.003
issn: 0963-9969
e-issn: 1873-7145
Appears in Collections:(CIAL) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
Show full item record

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.