Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/126489
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Fundamental aspects of the nucleic acid i-motif structures |
Autor: | Benabou, Sanae; Aviñó, Anna CSIC ORCID; González, Carlos CSIC ; Eritja Casadellà, Ramón CSIC ORCID ; Gargallo, Raimundo | Palabras clave: | Chemical stability Nucleic acids Oncogenic viruses Base pairs Building blockes ph value G-quadruplexes Promoter region I-motif In-vivo Chemical modification |
Fecha de publicación: | 2014 | Editor: | Royal Society of Chemistry (UK) | Citación: | RSC Advances 4: 26956-26980 (2014) | Resumen: | The i-motif structure is formed in cytosine-rich sequences, its building block being the cytosine·cytosine + base pair. This structure is particularly stable at pH values below physiological (∼7.4) and, because of that, it has not attracted as much biological interest as other non-canonical structures such as the G-quadruplex. Nowadays, the proposal of potential roles in vivo, as well as nanotechnological applications, has produced an increasing interest in its study. In this context, the present work provides an overall picture of the i-motif structure. Those aspects related to formation and stability, such as chemical modifications or the interaction with ligands, are discussed. Special attention has been made to the i-motif structures that could have a hypothetical role in vivo, such as those present near the promoter region of several oncogenes. | Versión del editor: | http://doi.org/10.1039/c4ra02129k | URI: | http://hdl.handle.net/10261/126489 | DOI: | 10.1039/c4ra02129k | E-ISSN: | 2046-2069 |
Aparece en las colecciones: | (IQAC) Artículos (IQF) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
review_Benabou2014.pdf | Artículo principal | 956,86 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
145
checked on 10-abr-2024
WEB OF SCIENCETM
Citations
138
checked on 27-feb-2024
Page view(s)
362
checked on 16-abr-2024
Download(s)
875
checked on 16-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.