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Title

Acute phase proteins increase with sarcoptic mange status and severity in Iberian ibex (Capra pyrenaica, Schinz 1838)

AuthorsRáez, Arian; Granados, José E.; Cerón, José J.; Cano-Manuel, Francisco Javier; Fandos, Paulino; Pérez, Jesús M.; Espinosa, José; Soriguer, Ramón C. ; López-Olvera, Jorge R.
KeywordsAcute phase proteins
Capra pyrenaica
Iberian ibex
Sarcoptes scabiei
Sarcoptic mange
Issue Date2015
PublisherSpringer
CitationParasitology Research 114: 4005- 4010 (2015)
AbstractSarcoptic mange is a contagious skin disease caused by Sarcoptes scabiei, affecting both domestic and wild mammals, including the Iberian ibex (Capra pyrenaica), a medium-sized mountain ungulate almost endemic to the Iberian Peninsula. Acute phase proteins (APPs) could be an indicator of sarcoptic mange disease and severity in Iberian ibex. Serum samples from 131 healthy and sarcoptic mange-affected Iberian ibexes were collected from 2005 to 2012 in Sierra Nevada Natural Space in southern Spain. Serum alpha-1-acid glycoprotein (AGP), serum amyloid A (SAA) and haptoglobin (Hp) concentrations were quantified, and statistically significant differences according to sarcoptic mange disease and severity were assessed. Both AGP and SAA were significantly higher in the sarcoptic mange-affected ibexes than in the healthy ones as well as in the severely affected ibexes as compared to those with less than 50 % of the body surface affected. For the first time, changes in APP are reported in relation to sarcoptic mange in Iberian ibex. It is also reported for the first time that the intensity of APP increase depends on the severity of sarcoptic mange, which could be related with the pathological secondary amyloidosis, leading to organ dysfunction in severely mange-affected animals. Species and population differences in the increase of APP in response to sarcoptic mange could indicate individual and population differences in the immune capability of each population to deal with mange, population prevalence and mortality being the last indicators of such sensitivity.
URIhttp://hdl.handle.net/10261/125435
DOI10.1007/s00436-015-4628-3
Identifiersdoi: 10.1007/s00436-015-4628-3
issn: 1432-1955
Appears in Collections:(EBD) Artículos
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