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dc.contributor.author | Ortiz-Bazán, María Ángeles | - |
dc.contributor.author | Gallo-Fernández, María | - |
dc.contributor.author | Saugar, Irene | - |
dc.contributor.author | Jiménez-Martín, Alberto | - |
dc.contributor.author | Vázquez, María Victoria | - |
dc.contributor.author | Tercero, José Antonio | - |
dc.date.accessioned | 2015-11-19T12:06:47Z | - |
dc.date.available | 2015-11-19T12:06:47Z | - |
dc.date.issued | 2014-10-09 | - |
dc.identifier | doi: 10.1016/j.celrep.2014.09.005 | - |
dc.identifier | issn: 2211-1247 | - |
dc.identifier.citation | Cell Reports 9: 460- 468 (2014) | - |
dc.identifier.uri | http://hdl.handle.net/10261/125357 | - |
dc.description.abstract | © 2014 The Authors. The RAD6/RAD18 pathway of DNA damage tolerance overcomes unrepaired lesions that block replication forks. It is subdivided into two branches: translesion DNA synthesis, which is frequently error prone, and the error-free DNA-damage-avoidance subpathway. Here, we show that Rad5HLTF/SHPRH, which mediates the error-free branch, has a major role in the response to DNA damage caused by methyl methanesulfonate (MMS) during chromosome replication, whereas translesion synthesis polymerases make only a minor contribution. Both the ubiquitin-ligase and the ATPase/helicase activities of Rad5 are necessary for this cellular response. We show that Rad5 is required for the progression of replication forks through MMS-damaged DNA. Moreover, supporting its role during replication, this protein reaches maximum levels during S phase and forms subnuclear foci when replication occurs in the presence of DNA damage. Thus, Rad5 ensures the completion of chromosome replication under DNA-damaging conditions while minimizing the risk of mutagenesis, thereby contributing significantly to genome integrity maintenance. | - |
dc.description.sponsorship | This work was supported by the Spanish Ministry of Economy and Competitiveness (MINECO; grants BFU2010-16989, BFU2013-43766 | - |
dc.publisher | Cell Press | - |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | - |
dc.title | Rad5 plays a major role in the cellular response to DNA damage during chromosome replication | - |
dc.type | artículo | - |
dc.identifier.doi | 10.1016/j.celrep.2014.09.005 | - |
dc.date.updated | 2015-11-19T12:06:48Z | - |
dc.description.version | Peer Reviewed | - |
dc.language.rfc3066 | eng | - |
dc.rights.license | http://creativecommons.org/licenses/by-nc-nd/3.0/ | - |
dc.relation.csic | Sí | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
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TerceroJ_Rad5PlaysaMajorRoleintheCellularResponse.pdf | 2,94 MB | Adobe PDF | Visualizar/Abrir |
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