Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/124982
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Physical exercise neuroprotects ovariectomized 3xTg-AD mice through BDNF mechanisms |
Autor: | García-Mesa, Yoelvis CSIC; Pareja-Galeano, Helios; Bonet-Costa, Vicent; Revilla, Susana CSIC; Gómez-Cabrera, M. C.; Gambini, Juan Pablo; Giménez-Llort, Lydia; Cristòfol, Rosa CSIC ; Viña, J.; Sanfeliu, Coral CSIC ORCID | Palabras clave: | 3xTg-AD mice Alzheimer's disease BDNF Behavioral tests Catalase Cognition Frailty Ovariectomy P-CREB Physical exercise |
Fecha de publicación: | jul-2014 | Editor: | International Society of Psyhconeuroendocrinology Elsevier |
Citación: | Psychoneuroendocrinology 45: 154-166 (2014) | Resumen: | Postmenopausal women may be more vulnerable to cognitive loss and Alzheimer's disease (AD) than premenopausal women because of their deficiency in estrogens, in addition to their usually older age. Aerobic physical exercise has been proposed as a therapeutic approach for maintaining health and well-being in postmenopausal women, and for improving brain health and plasticity in populations at high risk for AD. To study the neuroprotective mechanisms of physical exercise in a postmenopausal animal model, we submitted previously ovariectomized, six-month old non-transgenic and 3xTg-AD mice to three months of voluntary exercise in a running wheel. At nine months of age, we observed lower grip strength and some exacerbation of the behavioral and psychological symptoms of dementia (BPSD)-like involving active exploratory activities. A similar major cognitive impairment was observed of ovariectomized 3xTg-AD mice in comparison with sham-operated 3xTg-AD mice. A reduction of bodily fitness and lack of retention of memory were observed in the ovariectomized non-transgenic mice. Physical exercise protected against all deleterious behaviors and normalized learning and memory. It also protected against body frailty, as expected. Analyses of hippocampal key markers of antioxidant and neuroplasticity signaling pathways, showed that ovariectomy impairs the activation of CREB through physical exercise. Furthermore, molecular and behavioral correlates suggested a central role of BDNF in the neuroprotection mediated by physical exercise therapy against apathy and memory loss induced by ovariectomy and the AD-genotype. © 2014 Elsevier Ltd. | Versión del editor: | http://dx.doi.org/10.1016/j.psyneuen.2014.03.021 | URI: | http://hdl.handle.net/10261/124982 | DOI: | 10.1016/j.psyneuen.2014.03.021 | Identificadores: | doi: 10.1016/j.psyneuen.2014.03.021 issn: 1873-3360 |
Aparece en las colecciones: | (IIBB) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Garcia-Mesa-Psychoneur-2014-v45-p154_post-print.pdf | 1,41 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
51
checked on 10-abr-2024
WEB OF SCIENCETM
Citations
50
checked on 29-feb-2024
Page view(s)
297
checked on 18-abr-2024
Download(s)
730
checked on 18-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.