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Título

Nanocomposites of iridium oxide and conducting polymers as electroactive phases in biological media

AutorMoral-Vico, Javier; Sánchez-Redondo, Sara CSIC; Lichtenstein, Mathieu CSIC; Suñol, Cristina CSIC ORCID ; Casañ Pastor, Nieves CSIC ORCID
Palabras claveConducting polymers
Cytotoxicity
Hybrid materials
Iridium oxide
Fecha de publicaciónmay-2014
EditorElsevier
CitaciónActa Biomaterialia 10(5): 2177-2186 (2014)
ResumenMuch effort is currently devoted to implementing new materials in electrodes that will be used in the central nervous system, either for functional electrostimulation or for tests on nerve regeneration. Their main aim is to improve the charge capacity of the electrodes, while preventing damaging secondary reactions, such as peroxide formation, occurring while applying the electric field. Thus, hybrids may represent a new generation of materials. Two novel hybrid materials are synthesized using three known biocompatible materials tested in the neural system: polypyrrole (PPy), poly(3,4- ethylenedioxythiophene) (PEDOT) and iridium oxide (IrO2). In particular, PPy-IrO2 and PEDOT-IrO2 hybrid nanocomposite materials are prepared by chemical polymerization in hydrothermal conditions, using IrO2 as oxidizing agent. The reaction yields a significant ordered new hybrid where the conducting polymer is formed around the IrO 2 nanoparticles, encapsulating them. Scanning electron microscopy and backscattering techniques show the extent of the encapsulation. Both X-ray photoelectron and Fourier transform infrared spectroscopies identify the components of the phases, as well as the absence of impurities. Electrochemical properties of the final phases in powder and pellet form are evaluated by cyclic voltammetry. Biocompatibility is tested with MTT toxicity tests using primary cultures of cortical neurons grown in vitro for 6 and 9 days. © 2013 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
Versión del editorhttp://dx.doi.org/10.1016/j.actbio.2013.12.051
URIhttp://hdl.handle.net/10261/124970
DOI10.1016/j.actbio.2013.12.051
Identificadoresdoi: 10.1016/j.actbio.2013.12.051
issn: 1878-7568
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