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Título: | New developments in the synthesis of oligonucleotide-peptide conjugates |
Autor: | Portela, Cecilia; Mascareñas, José L.; Albericio, Fernando CSIC ORCID; Eritja Casadellà, Ramón CSIC ORCID ; Mazzini, Stefania; Caminal, Clara; Ramos, Roger CSIC; Ocampo, Sandra M. CSIC | Palabras clave: | Leucine zipper Oligonucleotide-peptide conjugates Pyrimidines t-butyl groups Molecular sequence data Oligonucleotides DNA fragment |
Fecha de publicación: | ago-2007 | Editor: | Taylor & Francis | Citación: | Nucleosides, Nucleotides and Nucleic Acids | Resumen: | The stability of oligodeoxynucleotides to trifluoroacetic acid is studied. Pyrimidine oligonucleotides were stable in the conditions used for the removal of t-butyl groups. Oligonucleotide-3′-peptide conjugates carrying pyrimidine oligonucleotides are prepared stepwise using peptide-supports and Fmoc, t-butyl strategy. Using this strategy we have prepared an oligonucleotide-peptide conjugate containing as peptide the leucine-rich fragment of FOS, a transcription factor involved in many important cellular processes. This conjugate has a long peptide sequence with a large number of trifunctional amino acids. | Versión del editor: | DOI: 10.1080/15257770701508216 | URI: | http://hdl.handle.net/10261/124968 | DOI: | 10.1080/15257770701508216 |
Aparece en las colecciones: | (IQAC) Artículos |
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Fichero | Descripción | Tamaño | Formato | |
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NNAN2007Portela.pdf | Artículo principal | 164,55 kB | Adobe PDF | Visualizar/Abrir |
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