Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/124899COMPARTIR / EXPORTAR:
 SHARE
 CORE
BASE
|
|
| Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
| Título: | AXL receptor tyrosine kinase is increased in patients with heart failure |
Autor: | Battle Perales, Montserrat; Recarte-Pelz, Pedro CSIC; García de Frutos, Pablo CSIC ORCID | Palabras clave: | AXL receptor tyrosine kinase Heart failure Myocardial damage |
Fecha de publicación: | 15-may-2014 | Editor: | Elsevier | Citación: | International Journal of Cardiology 173(3): 402-409 (2014) | Resumen: | Background AXL is a membrane receptor tyrosine kinase highly expressed in the heart and has a conspicuous role in cardiovascular physiology. The role of AXL in heart failure (HF) has not been previously addressed. Methods and results AXL protein was enhanced 6-fold in myocardial biopsies of end-stage HF patients undergoing heart transplantation compared to controls from heart donors (P < 0.0001). Next, we performed a transversal study of patients with chronic HF (n = 192) and a group of controls with no HF (n = 67). sAXL and BNP circulating levels were quantified and clinical and demographic data were collected. sAXL levels in serum were higher in HF (86.3 ± 2.0 ng/mL) than in controls (67.8 ± 2.0 ng/mL; P < 0.0001). Also, sAXL correlated with several parameters associated with worse prognosis in HF. Linear regression analysis indicated that serum creatinine, systolic blood pressure and atrial fibrillation, but not BNP levels, were predictive of sAXL levels. Cox regression analysis indicated that high sAXL values at enrollment time were related to the major HF events (all-cause mortality, heart transplantation and HF hospitalizations) at one year follow-up (P < 0.001), adding predictive value to high BNP levels. Conclusions Myocardial expression and serum concentration of AXL is elevated in HF patients compared to controls. Furthermore, peripheral sAXL correlates with parameters associated with the progression of HF and with HF events at short term follow-up. All together these results suggest that sAXL could belong to a new molecular pathway involved in myocardial damage in HF, independent from BNP. © 2014 Elsevier Ireland Ltd. | Descripción: | Montserrat Batlle et al. | Versión del editor: | http://dx.doi.org/10.1016/j.ijcard.2014.03.016 | URI: | http://hdl.handle.net/10261/124899 | DOI: | 10.1016/j.ijcard.2014.03.016 | Identificadores: | doi: 10.1016/j.ijcard.2014.03.016 issn: 1874-1754 |
| Aparece en las colecciones: | (IIBB) Artículos |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| Batlle-IJC-2014-v173-p402.pdf | 283,13 kB | Adobe PDF |  Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
27
checked on 27-mar-2024
SCOPUSTM
Citations
45
checked on 15-abr-2024
WEB OF SCIENCETM
Citations
42
checked on 29-feb-2024
Page view(s)
531
checked on 19-abr-2024
Download(s)
556
checked on 19-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.