Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/124792COMPARTIR / EXPORTAR:
 SHARE
 CORE
BASE
|
|
| Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
| Título: | C/EBPβ and nuclear factor of activated T cells differentially regulate Adamts-1 induction by stimuli associated with vascular remodeling |
Autor: | Oller, Jorge; Alfranca, Arántzazu; Méndez-Barbero, Nerea; Campanero, Miguel R. CSIC ORCID; Redondo, Juan Miguel CSIC ORCID | Fecha de publicación: | 2015 | Editor: | American Society for Microbiology | Citación: | Molecular and Cellular Biology 35(19): 3409-3422 (2015) | Resumen: | Emerging evidence indicates that the metalloproteinase Adamts-1 plays a significant role in the pathophysiology of vessel remodeling, but little is known about the signaling pathways that control Adamts-1 expression. We show that vascular endothelial growth factor (VEGF), angiotensin-II, interleukin-1β, and tumor necrosis factor α, stimuli implicated in pathological vascular remodeling, increase Adamts-1 expression in endothelial and vascular smooth muscle cells. Analysis of the intracellular signaling pathways implicated in this process revealed that VEGF and angiotensin-II upregulate Adamts-1 expression via activation of differential signaling pathways that ultimately promote functional binding of the NFAT or C/EBPβ transcription factors, respectively, to the Adamts-1 promoter. Infusion of mice with angiotensin-II triggered phosphorylation and nuclear translocation of C/EBPβ proteins in aortic cells concomitantly with an increase in the expression of Adamts-1, further underscoring the importance of C/EBPβ signaling in angiotensin-II-induced upregulation of Adamts-1. Similarly, VEGF promoted NFAT activation and subsequent Adamts-1 induction in aortic wall in a calcineurin-dependent manner. Our results demonstrate that Adamts-1 upregulation by inducers of pathological vascular remodeling is mediated by specific signal transduction pathways involving NFAT or C/EBPβ transcription factors. Targeting of these pathways may prove useful in the treatment of vascular disease. | Descripción: | et al. | Versión del editor: | https://doi.org/10.1128/MCB.00494-15 | URI: | http://hdl.handle.net/10261/124792 | DOI: | 10.1128/MCB.00494-15 | Identificadores: | doi: 10.1128/MCB.00494-15 issn: 0270-7306 e-issn: 1098-5549 |
| Aparece en las colecciones: | (IIBM) Artículos |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| vascularemodeling.pdf | 5,79 MB | Adobe PDF |  Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
9
checked on 23-abr-2024
SCOPUSTM
Citations
17
checked on 23-abr-2024
WEB OF SCIENCETM
Citations
16
checked on 26-feb-2024
Page view(s)
306
checked on 24-abr-2024
Download(s)
283
checked on 24-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.