English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/124658
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE
Exportar a otros formatos:

Title

E1A directly binds and regulates the P/CAF acetyltransferase

AuthorsReid, Juliet L.; Bannister, Andrew J.; Zegerman, Philip; Martínez-Balbás, Marian ; Kouzarides, Tony
KeywordsAcetyltransferase
CAF
E1A
Myogenesis
P
Transcription
Issue Date3-Aug-1998
PublisherEuropean Molecular Biology Organization
CitationEMBO Journal 17(15): 4469-4477 (1998)
AbstractThe P/CAF protein has intrinsic histone acetyltransferase (HAT) activity and is capable of binding the transcriptional co-activator CBP. Here we show that P/CAF can regulate transcription and that this function is independent of its binding to CBP. The HAT domain of P/CAF has transcriptional activation potential in yeast. In mammalian cells P/CAF can stimulate transcription of the RSV promoter, using the activity of its HAT domain. We show that the adenovirus protein E1A targets P/CAF and sequesters its transcriptional activity. Binding of E1A to P/CAF is direct, independent of CBP and requires residues within E1A conserved region 1. We find that the P/CAF binding residues in E1A are within a motif shown to be essential for efficient disruption of myogenesis by E1A. The fact that E1A can directly bind and regulate the activity of P/CAF, independently of its regulation of CBP, highlights an important role for P/CAF in the process of cell differentiation
Publisher version (URL)http://dx.doi.org/10.1093/emboj/17.15.4469
URIhttp://hdl.handle.net/10261/124658
DOI10.1093/emboj/17.15.4469
ISSN0261-4189
Appears in Collections:(IBMB) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.