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Title

In vitro caloric restriction induces protective genes and functional rejuvenation in senescent SAMP8 astrocytes.

AuthorsGarcía-Matas, Silvia ; Paul, Rajib K.; Molina-Martínez, Patricia ; Palacios, Héctor; Gutiérrez, Vincent; Corpas, Rubén ; Pallàs, Mercè; Cristòfol, Rosa ; Cabo, Rafael de; Sanfeliu, Coral
KeywordsAstrocytes
Caloric restriction
Mitochondria
Oxidative stress
RNA microarrays
Issue Date25-Feb-2015
PublisherAnatomical Society of Great Britain and Ireland
CitationAging Cell 14(3): 334-344 (2015)
AbstractAstrocytes are key cells in brain aging, helping neurons to undertake healthy aging or otherwise letting them enter into a spiral of neurodegeneration. We aimed to characterize astrocytes cultured from senescence-accelerated prone 8 (SAMP8) mice, a mouse model of brain pathological aging, along with the effects of caloric restriction, the most effective rejuvenating treatment known so far. Analysis of the transcriptomic profiles of SAMP8 astrocytes cultured in control conditions and treated with caloric restriction serum was performed using mRNA microarrays. A decrease in mitochondrial and ribosome mRNA, which was restored by caloric restriction, confirmed the age-related profile of SAMP8 astrocytes and the benefits of caloric restriction. An amelioration of antioxidant and neurodegeneration-related pathways confirmed the brain benefits of caloric restriction. Studies of oxidative stress and mitochondrial function demonstrated a reduction of oxidative damage and partial improvement of mitochondria after caloric restriction. In summary, caloric restriction showed a significant tendency to normalize pathologically aged astrocytes through the activation of pathways that are protective against the age-related deterioration of brain physiology. © 2014 The Authors
Publisher version (URL)http://dx.doi.org/10.1111/acel.12259
URIhttp://hdl.handle.net/10261/124613
DOI10.1111/acel.12259
Identifiersdoi: 10.1111/acel.12259
issn: 1474-9718
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