Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/124401
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Squalene targets pro- and anti-inflammatory mediators and pathways to modulate over-activation of neutrophils, monocytes and macrophages |
Autor: | Cárdeno, Ana; Aparicio-Soto, Marina; Montserrat-de la Paz, Sergio CSIC ORCID; Bermúdez, Beatriz CSIC ORCID; Muriana, Francisco J. G. CSIC ORCID ; Alarcón de la Lastra, C. | Fecha de publicación: | 2015 | Editor: | Elsevier | Citación: | Journal of Functional Foods 14: 779- 790 (2015) | Resumen: | Squalene is a natural triterpene consumed as an integral part of the human diet. Increasing evidence demonstrates that squalene has antioxidant, cardioprotective and anti-carcinogenic activities. Nevertheless, its anti-inflammatory properties remain unclear. The effects of squalene on lipopolysaccharide (LPS)-mediated inflammatory response in murine macrophages and human monocytes and neutrophils were investigated. Squalene reduced intracellular levels of ROS, nitrites, cytokines (TNF-α, IL-1β, IL-6 and IFN-γ) and pro-inflammatory enzymes (iNOS, COX-2 and MPO), including a decreased expression of TLR4 and key proteins for signalling pathways mediated by NF-κB (IκBα), MAPKs (JNK) and MMPs (1, 3 and 9). In addition, squalene enhanced expression levels of anti-inflammatory enzymes (HO-1) and transcription factors (Nrf2 and PPARγ). This study establishes that squalene has significant potential for management of inflammatory conditions characterized by an over-activation of neutrophils/monocytes/macrophages and thereby for the efficient termination of the inflammatory response. | URI: | http://hdl.handle.net/10261/124401 | DOI: | 10.1016/j.jff.2015.03.009 | ISSN: | 1756-4646 |
Aparece en las colecciones: | (IG) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Postprint_2015_JFunctFood_V14_P779.pdf | 472,67 kB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
78
checked on 22-abr-2024
WEB OF SCIENCETM
Citations
68
checked on 27-feb-2024
Page view(s)
357
checked on 22-abr-2024
Download(s)
573
checked on 22-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Este item está licenciado bajo una Licencia Creative Commons