Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/124317
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Constitutive hippocampal cholesterol loss underlies poor cognition in old rodents |
Autor: | Martín, Mauricio G. CSIC ORCID; Ahmed, Tariq; Korovaichuk, Alejandra CSIC; Venero, César CSIC ORCID; Menchón, Silvia A.; Salas, Isabel; Munck, Sebastian; Herreras, Óscar CSIC ORCID ; Balschun, Detlef; Dotti, Carlos G. CSIC ORCID | Fecha de publicación: | 30-may-2014 | Citación: | EMBO Molecular Medicine 6: 902- 917 (2014) | Resumen: | Cognitive decline is one of the many characteristics of aging. Reduced long-term potentiation (LTP) and long-term depression (LTD) are thought to be responsible for this decline, although the precise mechanisms underlying LTP and LTD dampening in the old remain unclear. We previously showed that aging is accompanied by the loss of cholesterol from the hippocampus, which leads to PI3K/Akt phosphorylation. Given that Akt de-phosphorylation is required for glutamate receptor internalization and LTD, we hypothesized that the decrease in cholesterol in neuronal membranes may contribute to the deficits in LTD typical of aging. Here, we show that cholesterol loss triggers p-Akt accumulation, which in turn perturbs the normal cellular and molecular responses induced by LTD, such as impaired AMPA receptor internalization and its reduced lateral diffusion. Electrophysiology recordings in brain slices of old mice and in anesthetized elderly rats demonstrate that the reduced hippocampal LTD associated with age can be rescued by cholesterol perfusion. Accordingly, cholesterol replenishment in aging animals improves hippocampal-dependent learning and memory in the water maze test. © 2014 The Authors. Published under the terms of the CC BY 4.0 license. | URI: | http://hdl.handle.net/10261/124317 | DOI: | 10.15252/emmm.201303711 | Identificadores: | doi: 10.15252/emmm.201303711 issn: 1757-4684 |
Aparece en las colecciones: | (CBM) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
MartinMauricio_ConstitutiveHippocampal.pdf | 2,55 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
40
checked on 24-abr-2024
SCOPUSTM
Citations
69
checked on 17-abr-2024
WEB OF SCIENCETM
Citations
64
checked on 29-feb-2024
Page view(s)
211
checked on 23-abr-2024
Download(s)
242
checked on 23-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.