English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/124044
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

Cancer-associated fibroblast and M2 macrophage markers together predict outcome in colorectal cancer patients

AuthorsHerrera, Mercedes; Casal, J. Ignacio ; Peña, Cristina
Issue Date21-Feb-2013
PublisherJohn Wiley & Sons
CitationCancer Sci 104 ( 4 ) 437–444 (2013)
AbstractTumor epithelial cells within a tumor coexist with a complex microenvironment in which a variety of interactions between its various components determine the behavior of the primary tumors. Cancer-associated fibroblasts (CAF) and M2 macrophages, characterized by high expression of different markers, including a-SMA, FSP1 and FAP, or CD163 and DCSIGN, respectively, are involved in the malignancy of different tumors. In the present study, expression of the above markers in CAF and M2 macrophages was analyzed using RT-PCR and immunohistochemistry in the normal mucosa and tumor tissue from a cohort of 289 colorectal cancer patients. Expression of CAF and M2 markers is associated with the clinical outcome of colorectal cancer patients. Moreover, the combination of CAF and M2 markers identifies three groups of patients with clear differences in the progression of the disease. This combined variable could be a decisive factor in the survival of advanced-stage patients. Taken together, these analyses demonstrate the prognostic involvement of interrelationships between DCSIGN, CD163, a-SMA, FSP1 and FAP markers in the survival of colon cancer patients.
Description8 p.-4 fig.-4 tab. Herrera, Mercedes et al.
Publisher version (URL)http://dx.doi.org/ 10.1111/cas.12096
URIhttp://hdl.handle.net/10261/124044
DOI10.1111/cas.12096
ISSN1347-9032
E-ISSN1349-7006
Appears in Collections:(CIB) Artículos
Files in This Item:
File Description SizeFormat 
Herrera_et_al-2013-Cancer_Science_2013.pdfArtículo principal1,29 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.