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BRCA1 Accelerates CtIP-Mediated DNA-End Resection

AuthorsCruz-García, Andrés; López-Saavedra, Ana ; Huertas Sánchez, Pablo
Issue Date9-Oct-2014
CitationCell Reports 9(2): 451-459 (2014)
AbstractDNA-end resection is a highly regulated and critical step in the response and repair of DNA double-strand breaks. In higher eukaryotes, CtIP regulates resection by integrating cellular signals via its posttranslational modifications and protein-protein interactions, including cell-cycle-controlled interaction with BRCA1. The role of BRCA1 in DNA-end resection is not clear. Here, we develop an assay to study DNA resection in higher eukaryotes at high resolution. We demonstrate that the BRCA1-CtIP interaction, albeit not essential for resection, modulates the speed at which this process takes place
Publisher version (URL)http://dx.doi.org/10.1016/j.celrep.2014.08.076
Identifiersissn: 2211-1247
Appears in Collections:(CABIMER) Artículos
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