English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/123480
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

Title

BRCA1 Accelerates CtIP-Mediated DNA-End Resection

AuthorsCruz-García, Andrés; López-Saavedra, Ana ; Huertas Sánchez, Pablo
Issue Date9-Oct-2014
CitationCell Reports 9(2): 451-459 (2014)
AbstractDNA-end resection is a highly regulated and critical step in the response and repair of DNA double-strand breaks. In higher eukaryotes, CtIP regulates resection by integrating cellular signals via its posttranslational modifications and protein-protein interactions, including cell-cycle-controlled interaction with BRCA1. The role of BRCA1 in DNA-end resection is not clear. Here, we develop an assay to study DNA resection in higher eukaryotes at high resolution. We demonstrate that the BRCA1-CtIP interaction, albeit not essential for resection, modulates the speed at which this process takes place
Publisher version (URL)http://dx.doi.org/10.1016/j.celrep.2014.08.076
URIhttp://hdl.handle.net/10261/123480
DOI10.1016/j.celrep.2014.08.076
Identifiersissn: 2211-1247
Appears in Collections:(CABIMER) Artículos
Files in This Item:
File Description SizeFormat 
BRCA1_Accelerates_CruzGarcia.pdf2,56 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.