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Title

Apolipoprotein D is involved in the mechanisms regulating protection from oxidative stress

AuthorsGanfornina, M. D. ; Torres-Schumann, Sonia; González, Constancio ; Bastiani, Michael J.; Sánchez, Diego
KeywordsLearning
Lipid peroxidation
Lipocalin
Locomotor behavior
Paraquat
Oxidative stress
Issue DateAug-2008
PublisherBlackwell Publishing
Anatomical Society of Great Britain and Ireland
CitationAging Cell 7(4): 506-515 (2008)
AbstractMany nervous system pathologies are associated with increased levels of apolipoprotein D (ApoD), a lipocalin also expressed during normal development and aging. An ApoD homologous gene in Drosophila, Glial Lazarillo, regulates resistance to stress, and neurodegeneration in the aging brain. Here we study for the first time the protective potential of ApoD in a vertebrate model organism. Loss of mouse ApoD function increases the sensitivity to oxidative stress and the levels of brain lipid peroxidation, and impairs locomotor and learning abilities. Human ApoD overexpression in the mouse brain produces opposite effects, increasing survival and preventing the raise of brain lipid peroxides after oxidant treatment. These observations, together with its transcriptional up-regulation in the brain upon oxidative insult, identify ApoD as an acute response protein with a protective and therefore beneficial function mediated by the control of peroxidated lipids.
DescriptionPMCID: PMC2574913; NIHMSID: NIHMS56479.-- et al.
Publisher version (URL)http://dx.doi.org/10.1111/j.1474-9726.2008.00395.x
URIhttp://hdl.handle.net/10261/122985
DOI10.1111/j.1474-9726.2008.00395.x
ISSN1474-9718
E-ISSN1474-9726
Appears in Collections:(IBGM) Artículos
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