English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/122967
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

DC FieldValueLanguage
dc.contributor.authorSuzuki, Kichiya-
dc.contributor.authorSánchez, Diego-
dc.contributor.authorGutiérrez, Gabriel-
dc.date.accessioned2015-10-02T14:08:27Z-
dc.date.available2015-10-02T14:08:27Z-
dc.date.issued2004-
dc.identifierdoi: 10.1016/j.gene.2004.06.027-
dc.identifierissn: 0378-1119-
dc.identifiere-issn: 1879-0038-
dc.identifier.citationGene 339: 49-59 (2004)-
dc.identifier.urihttp://hdl.handle.net/10261/122967-
dc.description.abstractWe previously identified two murine secretory proteins, mE-RABP(Lcn5) and mEP17(Lcn8), belonging to the lipocalin family and specifically expressed in the epididymis. The genes are contiguous and localized on mouse chromosome 2. We now show that five other related lipocalin genes, Lcn9, Lcn10, Lcn11, Lcn12, and Lcn13, that evolved by in situ tandem duplication are present on the same locus. Lcn9, Lcn10, Lcn12, and Lcn13 genes, like Lcn5 and Lcn8 genes, are specifically expressed in the mouse epididymis. However, each gene has a distinct spatial expression within the epididymis and different regulation. Analysis of the human genome sequence shows the presence of genes encoding lipocalins with genomic organization, chromosomal arrangement, and orientation similar to that of the corresponding murine genes, indicating that the epididymal cluster is evolutionary conserved. A phylogenetic analysis of the new epididymal proteins reveals their spread position in the lipocalin protein family tree. This suggests the preservation of the regulatory sequences, while protein sequences have greatly diverged, reflecting functional diversity and possibly multifunctionality. In terms of the cluster ancestry, epididymal expression possibly appeared in a PGDS-like lipocalin in amniotes, and the duplications generating the cluster occurred at least in the common ancestor of rodents and primates. The presence and conservation of a cluster of five genes encoding epididymal lipocalins, differently regulated and regionalized in the epididymis, strongly suggests that these proteins may play an important role for male fertility. © 2004 Elsevier B.V. All rights reserved.-
dc.description.sponsorshipThis work was supported in part by the National Institute of Child Health and Human Development (HD36900) and by funds from the Ernst Schering Research Foundation/Rockefeller Foundation.-
dc.publisherElsevier-
dc.rightsclosedAccess-
dc.titleMolecular evolution of epididymal lipocalin genes localized on mouse chromosome 2-
dc.typeartículo-
dc.identifier.doi10.1016/j.gene.2004.06.027-
dc.date.updated2015-10-02T14:08:28Z-
dc.description.versionPeer Reviewed-
dc.language.rfc3066eng-
dc.contributor.funderRockefeller Foundation-
dc.contributor.funderNational Institute of Child Health and Human Development (US)-
dc.contributor.funderErnst Schering Foundation-
dc.relation.csic-
dc.identifier.funderhttp://dx.doi.org/10.13039/100000877es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/100000071es_ES
dc.identifier.funderhttp://dx.doi.org/10.13039/501100001660es_ES
Appears in Collections:(IBGM) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show simple item record
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.