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Título: | Anti-adhesive activity of cranberry phenolic compounds and their microbial-derived metabolites against uropathogenic Escherichia coli in bladder epithelial cell cultures |
Autor: | González de Llano, Dolores CSIC ORCID ; Esteban-Fernández, Adelaida CSIC; Sánchez-Patán, Fernando CSIC; Martín-Álvarez, Pedro J. CSIC ORCID; Moreno-Arribas, M. Victoria CSIC ORCID ; Bartolomé, Begoña CSIC ORCID | Fecha de publicación: | 2015 | Editor: | Multidisciplinary Digital Publishing Institute | Citación: | International Journal of Molecular Sciences 16(6): 12119-12130 (2015) | Resumen: | Cranberry consumption has shown prophylactic effects against urinary tract infections (UTI), although the mechanisms involved are not completely understood. In this paper, cranberry phenolic compounds and their potential microbial-derived metabolites (such as simple phenols and benzoic, phenylacetic and phenylpropionic acids) were tested for their capacity to inhibit the adherence of uropathogenic Escherichia coli (UPEC) ATCC®53503™ to T24 epithelial bladder cells. Catechol, benzoic acid, vanillic acid, phenylacetic acid and 3,4-dihydroxyphenylacetic acid showed anti-adhesive activity against UPEC in a concentration-dependent manner from 100-500 µM, whereas procyanidin A2, widely reported as an inhibitor of UPEC adherence on uroepithelium, was only statistically significant (p < 0.05) at 500 µM (51.3% inhibition). The results proved for the first time the anti-adhesive activity of some cranberry-derived phenolic metabolites against UPEC in vitro, suggesting that their presence in the urine could reduce bacterial colonization and progression of UTI. | Descripción: | This is an open access article distributed under the Creative Commons Attribution License.-- This article belongs to the Special Issue Phenolics and Polyphenolics 2015. | Versión del editor: | http://dx.doi.org/10.3390/ijms160612119 | URI: | http://hdl.handle.net/10261/122811 | DOI: | 10.3390/ijms160612119 | Identificadores: | doi: 10.3390/ijms160612119 issn: 1422-0067 |
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