Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/122590
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Morales-Martínez, Adela | es_ES |
dc.contributor.author | Dobrzynska, Agnieszka | es_ES |
dc.contributor.author | Askjaer, Peter | es_ES |
dc.date.accessioned | 2015-09-24T11:21:25Z | - |
dc.date.available | 2015-09-24T11:21:25Z | - |
dc.date.issued | 2015-02-04 | - |
dc.identifier.citation | Journal of Cell Science 128(6): 1090-196 (2015) | es_ES |
dc.identifier.issn | 0021-9533 | - |
dc.identifier.uri | http://hdl.handle.net/10261/122590 | - |
dc.description.abstract | The inner nuclear membrane proteins emerin and LEMD2 have both overlapping and separate functions in regulation of nuclear organization, gene expression and cell differentiation. We report here that emerin (EMR-1) and LEM domain protein 2 (LEM-2) are expressed in all tissues throughout Caenorhaditis elegans development but their relative distribution differs between cell types. The ratio of EMR-1 to LEM-2 is particularly high in contractile tissues, intermediate in neurons and hypodermis and lowest in intestine and germ line. We find that LEM-2 is recruited earlier than EMR-1 to reforming nuclear envelopes, suggesting the presence of separate mitotic membrane compartments and specific functions of each protein. Concordantly, we observe that nuclei of lem-2 mutant embryos, but not of emr-1 mutants, have reduced nuclear circularity. Finally, we uncover a so-far-unknown role of LEM-2 in nuclear separation and anchoring of microtubule organizing centers. | es_ES |
dc.description.sponsorship | This work was funded by the Spanish Ministry of Economy and Competitiveness [grant numbers BFU2010-15478 and BFU2013-42709P], and the Autonomous Government of Andalusia [grant number P08-CVI-3920]. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Company of Biologists | - |
dc.relation | info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2013-42709-P | - |
dc.relation.isversionof | Postprint | - |
dc.rights | openAccess | es_ES |
dc.subject | Caenorhabditis elegans | es_ES |
dc.subject | LEMD2 | es_ES |
dc.subject | Nuclear envelope | es_ES |
dc.subject | LINC | es_ES |
dc.subject | Emerin | es_ES |
dc.subject | Laminopathy | es_ES |
dc.title | Inner nuclear membrane protein LEM-2 is required for correct nuclear separation and morphology in C. elegans | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1242/jcs.164202 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1242/jcs.164202 | es_ES |
dc.identifier.e-issn | 1477-9137 | - |
dc.contributor.funder | Ministerio de Economía y Competitividad (España) | - |
dc.contributor.funder | Junta de Andalucía | - |
dc.relation.csic | Sí | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100003329 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/501100011011 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
Aparece en las colecciones: | (CABD) Artículos |
Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
---|---|---|---|---|
Inner nuclear.pdf | 2,94 MB | Adobe PDF | Visualizar/Abrir |
CORE Recommender
SCOPUSTM
Citations
26
checked on 21-abr-2024
WEB OF SCIENCETM
Citations
23
checked on 19-feb-2024
Page view(s)
336
checked on 23-abr-2024
Download(s)
369
checked on 23-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.