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Differential spatial and structural organization of the X chromosome underlies dosage compensation in C. elegans

AuthorsSharma, Rahul; Jost, Daniel; Kind, Jop; Gómez-Saldívar, Georgina ; Steensel, Bas van; Askjaer, Peter ; Vaillant, Cédric; Meister, Peter
Issue DateDec-2014
PublisherCold Spring Harbor Laboratory Press
CitationGenes and Development 28: 2591-2596 (2014)
AbstractThe adjustment of X-linked gene expression to the X chromosome copy number (dosage compensation [DC]) has been widely studied as a model of chromosome-wide gene regulation. In Caenorhabditis elegans, DC is achieved by twofold down-regulation of gene expression from both Xs in hermaphrodites. We show that in males, the single X chromosome interacts with nuclear pore proteins, while in hermaphrodites, the DC complex (DCC) impairs this interaction and alters X localization. Our results put forward a structural model of DC in which X-specific sequences locate the X chromosome in transcriptionally active domains in males, while the DCC prevents this in hermaphrodites.
DescriptionThis article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months. After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International).
Publisher version (URL)http://dx.doi.org/10.1101/gad.248864.114
Appears in Collections:(CABD) Artículos
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