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Title

Method for the production of complex repertoires of recombinant molecules

Other TitlesMétodo de producción de repertorios complejos de moléculas recombinantes
AuthorsOrzáez, Diego ; Julve, José Manuel ; Granell, Antonio ; Sarrion-Perdigones, Alejandro ; Gutiérrez Cabrera, Carlos
Issue Date27-Mar-2014
CitationWO2014044892 A1
Abstract[EN] The invention relates to a method for the production of complex repertoires of recombinant molecules in a consistent and reproducible manner, comprising the transient generation of multi-transgenic plants that generate somatic mosaics induced by viral replicons that are mutually exclusive. The invention also relates to the multi-transgenic plant or a fragment of same obtained in this way, as well as to extracts or purified fractions thereof, which represent complex repertoires of recombinant molecules, preferably recombinant proteins selected from among: enzymes, immunoglobulins, membrane receptors, intracellular receptors, lectins, polyclonal antibodies, antidotes based on anti-serums, immunological serums for passive immunity, and intravenous immunoglobulins
[ES] La presente invención describe un método de producción de repertorios complejos de moléculas recombinantes de forma consistente y reproducible, mediante la generación de forma transitoria de plantas multi-transgénicas que dan lugar a mosaicos somáticos inducidos por replicones virales que se excluyen entre sí. La presente invención también hace referencia a la planta multi-transgénica o un fragmento de la misma así obtenida, así como a los extractos o fracciones purificadas de las mismas que representen repertorios complejos de moléculas recombinantes, preferentemente proteínas recombinantes seleccionadas entre: enzimas, inmunoglobulinas, receptores de membrana, receptores intracelulares, lectinas, anticuerpos policlonales, antivenenos basados en antisueros, sueros inmunológicos para inmunidad pasiva, e inmunoglobulinas intravenosas
URIhttp://hdl.handle.net/10261/122328
Appears in Collections:(IBMCP) Patentes
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