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Título: | Magnetic nanocapsules based on natural polymers |
Autor: | Matteis, Laura de; Fernández-Pacheco, Rodrigo; Marquina, Clara CSIC ORCID ; Ibarra, M. Ricardo CSIC ORCID; Fuente, Jesús M. de la CSIC ORCID | Fecha de publicación: | 2013 | Editor: | Federation of European Microbiological Societies | Citación: | EUROMAT 2013 | Resumen: | Natural polymer-based nanocomposites constitute a fascinating interdisciplinary area of materials science since their high biocompatibility and biodegradability allow their application in biomedicine, as for tissue engineering, regeneration and controlled release. When the filler is constituted by magnetic nanoparticles, their field of application becomes even broader, extending to magnetic hyperthermia and magnetic resonance imaging. The use of magnetic nanoparticles in bio-applications depends on their water stability and biocompatibility, which are strictly related to their composition and synthetic route. These issues constitute a big challenge in the pharmaceutical development of new products and they have generated a continuously evolving research field. The encapsulation into natural polymeric matrices is a suitable solution for providing the nanoparticles with the required water- and biocompatibility. The use of such kind of polymers in encapsulation processes allows the synthesis of composites with nanoparticles entrapped and confined in a well defined volume, ideally separated one from each other by the polymer network barriers. In the case of magnetic nanoparticles this aspect is particularly interesting: during the embedding process the formation of the polymer network will prevent an increase in the nanoparticles aggregation state by keeping the inter-particle distances so that the intensity of the magnetic interactions does not increase. This work reports the encapsulation of ferrite nanoparticles of difficult handling, in different natural polymer nanobeads selected as alternatives to increase nanoparticles water stability and biocompatibility. In each case a proper optimization of the composite synthetic process has been carried out in order to obtain nanosized, water-compatible polymeric magnetic capsules. The physico-chemical and magnetic characterization of the matrices has been performed; in particular an in-depth electron microscopy characterization has been carried out to determine the magnetic nanoparticle-polymer interaction. The reported results open the way for the biomedical application of water non-compatible magnetic nanoparticles and they also represent a feasibility test for a future characterization of other nanosized polymeric materials. | Descripción: | Resumen del póster presentado al "European Congress and Exhibition on Advanced Materials Processes" celebrado en Sevilla (España) del 8 al 13 de septiembre de 2013.-- et al. | URI: | http://hdl.handle.net/10261/122239 |
Aparece en las colecciones: | (ICMA) Comunicaciones congresos |
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