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Title

Emerging biological functions of the Vaccinia-Related Kinase (VRK) family

AuthorsKlerkx, Elke P. F. ; Lazo, Pedro A. ; Askjaer, Peter
KeywordsProtein kinase
VRK1
VRK2
Cell signaling
Transcription factor
Nuclear envelope
Issue DateJun-2009
PublisherUniversidad de Murcia
CitationHistology and Histopathology 24(6): 749-759 (2009)
AbstractThe Vaccinia-Related Kinases (VRKs) branched off early from the family of casein kinase (CK) I and compose a relatively uncharacterized family of the kinome. The VRKs were discovered due to their close sequence relation to the vaccinia virus B1R serine/threonine kinase. They were first described in phosphorylation of transcription factors that led to the discovery of an autoregulatory mechanism between VRK and the tumor suppressor transcription factor p53. The relevance of VRKs has broadened recently by introduction of its members as essential regulators in cell signaling, nuclear envelope dynamics, chromatin modifications, apoptosis and cellular stress response. Several phosphorylation substrates have been described, as well as the first positive and negative regulators of VRK. We provide an overview of the VRKs across species and discuss the wide diversity of cellular and organismal requirements for this kinase family.
Description11 pages, 5 figures, 1 table.-- PMID: 19337973 [PubMed].
Publisher version (URL)http://www.hh.um.es/Abstracts/Vol_24/24_6/24_6_749.htm
URIhttp://hdl.handle.net/10261/12217
ISSN0213-3911
Appears in Collections:(IBMCC) Artículos
(CABD) Artículos
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