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Título: | R Loops: From Transcription Byproducts to Threats to Genome Stability |
Autor: | Aguilera, Andrés CSIC ORCID; García-Muse, Tatiana CSIC ORCID | Fecha de publicación: | abr-2012 | Editor: | Elsevier | Citación: | Molecular Cell 46(2): 115-124 (2012) | Resumen: | RNA:DNA hybrid structures known as R loops were thought to be rare byproducts of transcription. In the last decade, however, accumulating evidence has pointed to a new view in which R loops form more frequently, impacting transcription and threatening genome integrity as a source of chromosome fragility and a potential cause of disease. Not surprisingly, cells have evolved mechanisms to prevent cotranscriptional R loop formation. Here we discuss the factors and cellular processes that control R loop formation and the mechanisms by which R loops may influence gene expression and the integrity of the genome. | Versión del editor: | http://dx.doi.org/10.1016/j.molcel.2012.04.009 | URI: | http://hdl.handle.net/10261/121558 | DOI: | 10.1016/j.molcel.2012.04.009 | ISSN: | 1097-2765 | E-ISSN: | 1097-4164 |
Aparece en las colecciones: | (CABIMER) Artículos |
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