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Title

Nano-objects for addressing the control of nanoparticle arrangement and performance in magnetic hyperthermia

AuthorsAndreu, Irene; Natividad, Eva; Solozábal, Laura; Roubeau, Olivier
KeywordsIron oxide magnetic nanoparticles
PLGA
Silica
Nano-object
Magnetic interactions
Specific absorption rate
Issue DateFeb-2015
PublisherAmerican Chemical Society
CitationACS Nano 9(2): 1408-1419 (2015)
AbstractOne current challenge of magnetic hyperthermia is achieving therapeutic effects with a minimal amount of nanoparticles, for which improved heating abilities are continuously pursued. However, it is demonstrated here that the performance of magnetite nanocubes in a colloidal solution is reduced by 84% when they are densely packed in three-dimensional arrangements similar to those found in cell vesicles after nanoparticle internalization. This result highlights the essential role played by the nanoparticle arrangement in heating performance, uncontrolled in applications. A strategy based on the elaboration of nano-objects able to confine nanocubes in a fixed arrangement is thus considered here to improve the level of control. The obtained specific absorption rate results show that nanoworms and nanospheres with fixed one- and two-dimensional nanocube arrangements, respectively, succeed in reducing the loss of heating power upon agglomeration, suggesting a change in the kind of nano-object to be used in magnetic hyperthermia.
Publisher version (URL)http://dx.doi.org/10.1021/nn505781f
URIhttp://hdl.handle.net/10261/121260
DOI10.1021/nn505781f
ISSN1936-0851
E-ISSN1936-086X
Appears in Collections:(ICMA) Artículos
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