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Title

A modelling study on transmission of the central oscillator in tremor by a motor neuron pool

AuthorsGallego, Juan Álvaro ; Dideriksen, Jakob L.; Farina, Dario; Rocón, Eduardo ; Holobar, Ales; Pons Rovira, José Luis
KeywordsModelling studies
Motor neurons
Correlation analysis
Neurons
Pathological tremors: Brain
Lakes
Multiscale models
Issue Date30-Aug-2011
CitationProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS 2011 (2011)
AbstractIn spite of decades of intense research, pathological tremors still constitute unknown disorders. This study addresses, based on a multi-scale model, the behavior of an entire pool of motor neurons in tremor, under the hypothesis that tremor is an oscillation of central origin commonly projected to all motor neurons that innervate a muscle. Our results show that under such conditions both paired discharges and enhanced motor neuron synchronization, two of the characteristic landmarks of tremor, emerge. Moreover, coherence and correlation analyses suggest that the central tremor oscillator is transmitted linearly by the motor neuron pool given that a small set (7 or 8) of motor neurons are sampled.
URIhttp://hdl.handle.net/10261/121016
DOIhttp://dx.doi.org/10.1109/IEMBS.2011.6090375
ISBN978-142444121-1
ISSN1557-170X
Appears in Collections:(IC) Comunicaciones congresos
(CAR) Comunicaciones congresos
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