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Título:	Gold nanoprisms for photothermal cell ablation in vivo
Autor:	Pino González de la Higuera, Pablo del; Fuente, Jesús M. de la CSIC ORCID; Tortiglione, Claudia
Fecha de publicación:	2014
Editor:	Future Medicine
Citación:	Nanomedicine 9(13): 1913-1922 (2014)
Resumen:	[Aim]: To develop new methodologies for selective cell ablation in a temporally and spatially precise fashion in model organisms. [Materials & methods]: living polyps (Hydra vulgaris) treated with gold nanoprisms were near-infrared (NIR) irradiated and the photothermal effects evaluated at whole-animal, cellular and molecular levels. [Results]: Nanoprisms showed good efficiency of internalization in living specimens, with no sign of toxicity; under NIR irradiation they induced cell death and the overexpression of the hsp70 gene. [Conclusion]: gold nanoprisms could be employed as efficient heat mediators in model organisms, and NIR-triggered cell ablation may represent a new advanced tool to study cell function. Solving bioethical and economical issues, invertebrates may provide alternative models bridging the gap between cell research and preclinical studies of photothermal therapy.
Descripción:	et al.
URI:	http://hdl.handle.net/10261/118304
DOI:	10.2217/nnm.14.100
Identificadores:	doi: 10.2217/nnm.14.100 issn: 1743-5889 e-issn: 1748-6963
Aparece en las colecciones:	(ICMA) Artículos

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Gold nanoprisms for photothermal cell ablation in vivo