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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Jaumot, Joaquim | - |
dc.contributor.author | Tauler, Romà | - |
dc.contributor.author | Gargallo, Raimundo | - |
dc.date.accessioned | 2009-03-24T10:49:29Z | - |
dc.date.available | 2009-03-24T10:49:29Z | - |
dc.date.issued | 2006-11-01 | - |
dc.identifier.citation | Analytical and Bioanalytical Chemistry 3358(1):76-89(2006) | en_US |
dc.identifier.issn | 1618-2642 | - |
dc.identifier.uri | http://hdl.handle.net/10261/11810 | - |
dc.description | 14 pages, 3 tables, 4 figures. | en_US |
dc.description.abstract | In this work, the application of a multivariate curve resolution procedure based on alternating least squares optimization (MCR-ALS) for the analysis of data from DNA microarrays is proposed. For this purpose, simulated and publicly available experimental data sets have been analyzed. Application of MCR-ALS, a method that operates without the use of any training set, has enabled the resolution of the relevant information about different cancer lines classification using a set of few components; each of these defined by a sample and a pure gene expression profile. From resolved sample profiles, a classification of samples according to their origin is proposed. From the resolved pure gene expression profiles, a set of over- or underexpressed genes that could be related to the development of cancer diseases has been selected. Advantages of the MCR-ALS procedure in relation to other previously proposed procedures such as principal component analysis are discussed. | en_US |
dc.description.sponsorship | This research was supported by the MEC (Grant No. BQU2003-0191) and the Generalitat de Catalunya (Grant No. 2001SGR00056). | en_US |
dc.format.extent | 19968 bytes | - |
dc.format.mimetype | application/msword | - |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | closedAccess | en_US |
dc.subject | Gene expression data | en_US |
dc.subject | DNA microarray | en_US |
dc.subject | Multivariate curve resolution | en_US |
dc.subject | Cancer | en_US |
dc.title | Exploratory data analysis of DNA microarrays by multivariate curve resolution | en_US |
dc.type | artículo | en_US |
dc.identifier.doi | 10.1016/j.ab.2006.07.028 | - |
dc.description.peerreviewed | Peer reviewed | en_US |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.ab.2006.07.028 | en_US |
dc.identifier.e-issn | 1618-2650 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
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