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dc.contributor.authorForns, Joan-
dc.contributor.authorFort, Marta-
dc.contributor.authorCasas, Maribel-
dc.contributor.authorCáceres, Alejandro-
dc.contributor.authorGuxens, M.-
dc.contributor.authorGascon, Mireia-
dc.contributor.authorGarcía-Esteban, Raquel-
dc.contributor.authorJúlvez, Jordi-
dc.contributor.authorGrimalt, Joan O.-
dc.contributor.authorSunyer, Jordi-
dc.date.accessioned2015-07-06T09:49:58Z-
dc.date.available2015-07-06T09:49:58Z-
dc.date.issued2015-07-06-
dc.identifier.urihttp://hdl.handle.net/10261/117586-
dc.description.abstractBackground: There is insufficient epidemiological evidence for deciding whether prenatal exposure to the current low-levels of metals in developed countries may affect neuropsychological function in early childhood. Objectives: Our goal was to evaluate potential neurotoxic effects of prenatal exposure to seven metals (cobalt, copper, arsenic, cadmium, antimony, thallium and lead), during the 1st and 3rd trimester of pregnancy, on child neuropsychological development at 4 years of age. Materials and methods: This study was based on a population-based birth cohort established in Sabadell (Catalonia, Spain) as part of the INMA [Environment and Childhood] Project. Metals were measured in 485 urine samples collected from mothers during the 1st and 3rd trimester of pregnancy. We assessed the neuropsychological development of 553 4-year-olds with the McCarthy Scales of Childrens' Abilitites (MSCA), together with their ADHD symptomatology, using the ADHD-DSM-IV criteria. A total of 385 children were included in the present study. Results: We found no statistically significant associations between metals and general cognitive scale or executive function of the MSCA. We found negative coefficients for the exposure to cadmium 1st trimester, cadmium 3rd trimester and lead 3rd trimester on the general cognitive score of MSCA, although these results were not significant. We did not find any association between prenatal exposure to metals and ADHD symptomatology at the age of 4 years. Conclusions: Our results do not suggest that prenatal exposure to current low-levels of metals impairs children's cognitive development during preschool years.es_ES
dc.description.sponsorshipa Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain b Universitat Pompeu Fabra, Barcelona, Spain c CIBER Epidemiologia y Salud Pública (CIBERESP), Barcelona, Spain d Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research, Barcelona, Catalonia, Spain e Institute for Risk Assessment Sciences, Division of Environmental Epidemiology, Utrecht University, Netherlands f Department of Environmental Health, Harvard School of Public Health, Boston, MA, United States g IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spaines_ES
dc.language.isoenges_ES
dc.relation.isversionofPreprintes_ES
dc.rightsopenAccesses_ES
dc.subjectChild developmentes_ES
dc.subjectEnvironmental exposurees_ES
dc.subjectHeavy metalses_ES
dc.subjectNervous systemes_ES
dc.subjectNeuropsychologyes_ES
dc.titleExposure to metals during pregnancy and neuropsychological development at the age of 4 yearses_ES
dc.typeartículoes_ES
dc.identifier.doi10.1016/j.neuro.2013.10.006-
dc.description.peerreviewedNoes_ES
dc.relation.publisherversion10.1016/j.neuro.2013.10.006es_ES
dc.relation.publisherversionhttps://doi.org/10.1016/j.neuro.2013.10.006-
dc.rights.licensehttp://www.sherpa.ac.uk/romeo/search.php?jtitle=neurotoxicology&issn=0161-813X&zetocpub=Elsevier&romeopub=Elsevier&fIDnum=|&mode=simple&la=es&version=&source=journal&sourceid=16087es_ES
dc.relation.csices_ES
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
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