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Bioactive chitosan nanoparticles loaded with retinyl palmitate: A simple route using ionotropic gelation

AuthorsFernández-Gutiérrez, Mar ; Bossio, Ornella; Gómez-Mascaraque, Laura G. ; Vázquez Lasa, Blanca; San Román, Julio
Ionic gelation
Retinyl palmitate
Issue Date2015
PublisherJohn Wiley & Sons
CitationMacromolecular Chemistry and Physics 216: 1321-1332 (2015)
AbstractNowadays, there is an increasing demand in incorporating antioxidants into biopolymeric nanoparticles (NPs) in order to enlarge their applications in the pharmaceutical and biomedical fields. The challenge of the work is to investigate the feasibility of encapsulating retinyl palmitate (RP) into chitosan (Ch) NP via ionotropic gelation. Two routes are addressed in the preparation of the systems, and they have an influence on the physicochemical properties of the NP in addition to the antioxidant amount loaded. The resulting RP-encapsulated NP has pseudo spherical morphology, average hydrodynamic diameters between 230 and 350 nm and zeta potential values between +12.5 and +30 mV, depending on RP load and procedure. Encapsulation efficiency ranges from about 35% to 64%, and the loading capacity between 4% and 10%. The antioxidant activity studied by the 1,1-diphenyl-2-picryl-hydrazyl (DPPH) assay and cytotoxicity of RP-loaded NP evaluated against human dermal fibroblasts is dependent on RP content and NP concentration.
Identifiersdoi: 10.1002/macp.201500034
issn: 1022-1352
e-issn: 1521-3935
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